DEXERYL Emollient Cream

Statistically significant effectiveness proven in clinical studies on over 1000 patients. These studies were done against a placebo or comparator, providing the highest level of scientific evidence.

Discover the Emollient Cream
DEXERYL Emollient Cream

DEXERYL: AN EFFECTIVE TREATMENT for the symptoms of dry skin in the context of ichthyosis

Dexeryl showed a significant decrease in xerosis1.

60% of patients saw a significant reduction of 50% in their condition symptoms in 28 days1

Percentage of patients with at least a 50% reduction in SRRC score at D28 (%). SRRC Score = Scaling Roughness Redness Cracks score: reference score for assessing skin dryness and ichthyosis based on these four criteria.  Graphic created by Pierre Fabre. Percentage of patients with at least a 50% reduction in SRRC score at D28 (%). SRRC Score = Scaling Roughness Redness Cracks score: reference score for assessing skin dryness and ichthyosis based on these four criteria.  Graphic created by Pierre Fabre.
  1. 92%

    of patients rated hydration as good or very good1,2

  2. 40%

    of patients consider that sweating has improved slightly or considerably1,2

  3. 80%

    of physicians in the clinical study found DEXERYL Emollient Cream to be effective in the management of ichthyosis in children1,2

1 - Blanchet-Bardon C et al. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. JEADV 2012

2 - After 3 months of use.

METHODOLOGY

Aim

To demonstrate the effectiveness of DEXERYL Emollient Cream in reducing the severity of ichthyosis.

Study

Phase III, international, multicentre, randomised, controlled, double-blind, parallel-group study: Dexeryl versus vehicle (placebo).

Population

231 children included with an average age of 8.3 years, suffering from a non-bullous form of ichthyosis: ichthyosis vulgaris (63.2%), X-linked recessive (14.7%), other (22.1%).

Dosage

2 applications daily.

Duration

12 weeks (4-week double-blind period with Dexeryl Cream or vehicle) followed by an open-label period with all patients treated with Dexeryl Cream (for 8 weeks). 

Primary evaluation criteria

Improvement of ichthyosis by monitoring the evolution of skin xerosis via the SRRC* score : percentage of patients with a 50% reduction in SRRC score at D28. 

Secondary evaluation criteria

Pruritus: assessed using a visual analogue scale (VAS). Global assessment (hydration capacity, improvement of perspiration): performed by each investigator and patient.

Tolerance

Twice-daily application of DEXERYL cream to the skin of children for 3 months did not induce any systemic or local adverse effects. DEXERYL cream has, therefore, proven to be safe and has a good tolerance profile.

All about ichthyosis: causes, symptoms and treatments

Ichthyosis? We should talk about ichthyosis because there are several forms of it of varying severity1,2. Ichthyosis is a rare genetic skin disease characterised by very dry skin and a fish-scale appearance. But what is ichthyosis? 

Find out more about ichthyosis
All about ichthyosis: causes, symptoms and treatments

Sources:

1 - Blanchet-Bardon C et al. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. JEADV 2012