Uraemic xerosis is a common chronic dermatological complication in patients with chronic renal failure, particularly those on renal dialysis.
of renal dialysis patients suffer from xerosis
of patients suffer from severe xerosis
The skin is dry, rough, cracked and scaly. Uraemic xerosis particularly affects the legs, back, chest and hands. It is often associated with severe itching.
Xerosis is present in approximately 75% of the renal dialysis population. Uraemic xerosis can be mild (30-40% of patients), moderate (35-50%) or severe in 15-30% of patients¹
In most cases, it disappears after a kidney transplant.
The cause is still unknown but is thought to be due to several factors: dehydration of the skin, alteration of the skin's barrier function, irritation due to external substances (e.g. surfactants in soaps) or internal substances such as the accumulation of uraemic toxins (waste products resulting from the degradation of proteins linked to the diet, for example)².
Treatment is based primarily on optimising the conditions under which dialysis is performed, but also on the daily application of emollients to improve symptoms. This complication should be treated by the dermatologist and the nephrologist at the same time to improve the quality of life of dialysis patients³.
DEXERYL provides patients with proven clinical studies.
DEXERYL supports you with emollient skin care and cleansers specially formulated for sensitive and dry skin.
DEXERYL Emollient Cream can be used to protect the skin and treat the signs and symptoms of dry skin, particularly in the context of uraemic xerosis.
1) Balaskas E., Szepietowski J.C., Bessis D., Ioannides D., Ponticelli C., Ghienne C., Taberly A., Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis Clin J Am Soc Nephrol. 2011; 6(4): 748-52
2) Szepietowski, J. C. (2004). Uraemic xerosis. Nephrology Dialysis Transplantation, 19(11), 2709-2712. https://doi.org/10.1093/ndt/gfh480
3) Dahbi N, Hocar O, Akhdari N, Amal S, Bassit N, Fadili W, et al. Skin manifestations in chronic haemodialysis patients. Nephrol Ther 2014; 10: 101-5